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arimidex
Arimidex® (anastrozole)
Active Life: 48 hours
Drug Class: Aromatase inhibitor (Oral)
Average Dose: 0.25 - 1.0 mg/day
Acne: Yes
Water Retention: No
High Blood Pressure: May reduce bp when using aromatizable steroids
Liver Toxic: Yes
Decrease HPTA function: No
Arimidex® (generic name is anastrozole) is a newer drug developed for the treatment of advanced breast cancer in women. It is manufactured by Zenica Pharmaceuticals and was approved for use in the United States at the end of December 1995. Specifically, Arimidex is the first in a new class of third-generation selective oral aromatase inhibitors.. It acts by blocking the enzyme aromatase, subsequently blocking the production of estrogen. Since many forms of breast cancer cells are stimulated by estrogen, it is hoped that by reducing amounts of estrogen in the body the progression of such a disease can be halted. This is the basic premise behind Nolvadex, except this drug blocks the action and not production of estrogen. The effects of Arimidex can be quite dramatic to say the least. A daily dose of one tablet (1 mg) can produce estrogen suppression greater than 80 % in treated patients. With the powerful effect this drug has on hormone levels, it is only to be used (clinically) by post-menopausal women whose disease has progressed following treatment with Nolvadex (tamoxifen citrate). Side effects like hot flushes and hair thinning can be present, and would no doubt be much more severe in pre-menopausal patients.
For the steroid using male athlete, Arimidex shows great potential. Up to this point, drugs like Nolvadex and Proviron have been our weapons against excess estrogen. These drugs, especially in combination, do prove quite effective. But Arimidex appears able to do the job much more efficiently, and with less hassle. A single tablet daily (1 mg), the same dose use clinically, seems to be all one needs for an exceptional effect (some even report excellent results with only 0.25 mg daily). When used with strong, readily aromatizing androgens such as Dianabol or testosterone, gynecomastia and water retention can be effectively blocked. In combination with Propecia (finasteride), we have a great advance. With the one drug halting estrogen conversion and the other blocking 5-alpha reduction , related side effects can be effectively minimized. Here the strong androgen testosterone could theoretically provide incredible muscular growth, while at the same time being as tolerable as nandrolone. Additionally the quality of the muscle should be greater, the athlete appearing harder and much more defined without holding excess water.
There are some concerns with using an aromatase inhibitor such as this during prolonged steroid treatment however. While it will effectively reduce estrogenic side effects, it will also block the beneficial properties of estrogen from becoming apparent (namely its effect on cholesterol values). Studies have clearly shown that when an aromatase inhibitor is used in conjunction with a steroid such as testosterone, suppression of HDL (good) cholesterol becomes much more pronounced. Apparently estrogen plays a role in minimizing the negative impact of steroid use. Since the estrogen receptor antagonist Nolvadex is shown not to display an anti-estrogenic effect on cholesterol values, it is certainly the preferred from of estrogen maintenance for those concerned with cardiovascular health.
Arimidex has another principle drawback, namely the great price of this drug. Tablets can easily sell for $10 each, becoming quite costly with regular use. Clearly the price of an ancillary drug can be much greater than the steroids themselves, a situation destined not to be popular with recreational bodybuilders. Competitors on the other hand are likely to welcome this item. It can ward off the side effects of strong androgen therapy much better than Nolvadex and/or Proviron, making heavy cycles much more comfortable. As the number of countries manufacturing this drug increases, we may be able to look forward to a reduction in price. Privately compounded versions of "liquid Arimidex" have also been formulated "for research purposes" are also available. Generic tabs are also available and these two forms represent a very cost-effective alternative for buying the brand name drug.
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About Winstrol
Winstrol - Stanozolol is a very commonly used anabolic steroid for cutting cycles. While many people will attempt to use Dianabol or even Anadrol for cutting cycles, I´ve really never heard of anyone using Stanozolol for anything except a cutting cycle. It´s a bit of a one-trick-pony in this respect. Let me repeat that: Stanozolol is a cutting drug. Not many people will argue for its use in a bulking cycle. It´s certainly not a very effective compound for treating anemia (1) and thus, one could rightly assume that its role in bulking cycles is very limited. One novel use for Winstrol in any cycle (perhaps even bulking) would be to use it at a very limited dose, in order to lower SHBG. (2) One of the properties of Winstrol is it´s profound ability to lower SHBG much more than other steroids. A dose of .2mg/kg lowered SHBG significantly, which would in turn, raise the amount of free testosterone circulating in the body. As with 99% of steroids, however, it´s important to note that suppression of your natural hormonal levels will occur (though perhaps not to the extent that it will with many other steroids).(10) As with running virtually any compound, testosterone supplementation (i.e. running test in a cycle containing Winstrol) is warranted to avoid possible sexual dysfunction.
Winstrol & Stanozol Side Effects
Adding it to a heavy bulking cycle could be problematic, as Stanozolol is a 17aa compound, meaning that it´s been altered to endure the first pass through your liver without being destroyed. This makes it an orally active compound; so many people choose to take the pills which are available from both legitimate pharmaceutical companies as well as Underground Labs. Unfortunately, since it is 17aa, it is also liver toxic& in fact; Stanozolol has one of the worst hepatoxicity (mg for mg) of any steroid. This is the reason its addition to a bulking cycle could be problematic; generally a bulking cycle will be very heavy, dosage wise as well as toxicity-wise. It also has undesirable results on Cholesterol, and a mere 6mgs/day of Stanozolol can lower HDL by 33% and raise LDL by 29% (3). Cardiac Hypertrophy, even at lower doses could be a concern with Winstrol as well (4) Thus, many people limit their intake of Stanozolol to precontest or Summer-cutting types of cycles. It´s generally accepted that due to the toxicity issues of Stanozolol, its use should be limited to 6 weeks& as with anything though, many people have run it for up to 12 weeks with no problems.
As it is available in both an oral form as well as an injectable form, and both contain the same compound, you might find this next part odd, but the injectable route actually produces greater nitrogen retention. (5) Another counterintuitive fact about Winstrol is that although the anabolic rating of this product is very high, not too many people report much weight gain off of it. Also, it has a very weak Androgen Receptor binding ability (6), which is kind of odd for a drug with Winstrol’s effects. unusual for a “cutting” steroid. Protein synthesis is reasonably high with Winstrol (7), although weight gain is low, paradoxically.
In all, this is a very odd compound, from a chemical/biological point of view. My personal experience with it was that it can be used as a cheap substitute for Anavar, although I prefer the latter. Also, the injections hurt like hell.. |
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